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Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

Dolnik, Anna ; Engelmann, Julia C. ; Scharfenberger-Schmeer, Maren ; Mauch, Julian ; Kelkenberg-Schade, Sabine ; Haldemann, Berit ; Fries, Tamara ; Krönke, Jan ; Kühn, Michael W. M. ; Paschka, Peter ; Kayser, Sabine ; Wolf, Stephan ; Gaidzik, Verena I. ; Schlenk, Richard F. ; Rücker, Frank G. ; Döhner, Hartmut ; Lottaz, Claudio ; Döhner, Konstanze ; Bullinger, Lars



Abstract

Acute myeloid leukemia (AML) is characterized by molecular heterogeneity. As commonly altered genomic regions point to candidate genes involved in leukemogenesis, we used microarray-based comparative genomic hybridization and single nucleotide polymorphism profiling data of 391 AML cases to further narrow down genomic regions of interest. Targeted resequencing of 1000 genes located in the ...

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