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Impact of lifestyle factors on preneoplastic changes in prophylactic oophorectomies of BRCA mutation carriers

Primas, Helga, Kroiss, Regina, Kalteis, Karin, Rappaport, Christine, Muhr, Daniela, Primas, Christian, Kubista, Ernst, Horvat, Reinhard, Oefner, Peter J., Singer, Christian F. and Wagner, Teresa (2012) Impact of lifestyle factors on preneoplastic changes in prophylactic oophorectomies of BRCA mutation carriers. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 21 (2), pp. 199-204.

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Abstract

BRCA mutation carriers are at high risk of developing ovarian cancer. Ovarian malignancies are usually identified at an advanced stage with poor prognosis, attributed to inadequate options of early detection. Because of its risk-reducing effect of nearly 96%, prophylactic salpingo-oophorectomy is still the leading option for risk-reduction in women with a positive BRCA mutation status. The ...

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Item type:Article
Date:March 2012
Additional Information (public):The Austrian Hereditary Breast and Ovarian Cancer Group
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
22252303PubMed ID
10.1097/CEJ.0b013e32834c9b22DOI
Classification:
NotationType
AdultMESH
AgedMESH
Family HealthMESH
FemaleMESH
Genes, BRCA1MESH
Genes, BRCA2MESH
HeterozygoteMESH
HumansMESH
Life StyleMESH
Middle AgedMESH
MutationMESH
Ovariectomy/statistics & numerical dataMESH
Overweight/geneticsMESH
Precancerous Conditions/pathologyMESH
Retrospective StudiesMESH
Risk FactorsMESH
Keywords:BRCA1; BRCA2; lifestyle factors; ovarian cancer; preneoplastic changes; prophylactic salpingo-oophorectomy
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30601
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