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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine

Gronwald, Wolfram, Klein, Matthias S., Zeltner, Raoul, Schulze, Bernd-Detlef, Reinhold, Stephan W., Deutschmann, Markus, Immervoll, Ann-Kathrin, Böger, Carsten A., Banas, Bernhard, Eckardt, Kai-Uwe and Oefner, Peter J. (2011) Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine. Kidney international 79 (11), pp. 1244-1253.

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Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based classification and analyzed urine specimens of 54 patients with ADPKD and slightly ...

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Item type:Article
Date:June 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
21389975PubMed ID
10.1038/ki.2011.30DOI
Classification:
NotationType
AdultMESH
Antihypertensive Agents/therapeutic useMESH
Artificial IntelligenceMESH
Biological Markers/urineMESH
Case-Control StudiesMESH
Diabetic Nephropathies/urineMESH
Diagnosis, DifferentialMESH
FemaleMESH
GermanyMESH
Glomerular Filtration RateMESH
HumansMESH
Kidney/physiopathologyMESH
Kidney Failure, Chronic/urineMESH
Kidney TransplantationMESH
Magnetic Resonance SpectroscopyMESH
MaleMESH
Methanol/urineMESH
Middle AgedMESH
Peptide MappingMESH
Polycystic Kidney, Autosomal Dominant/urineMESH
Predictive Value of TestsMESH
PrognosisMESH
Proteinuria/urineMESH
Proteomics/methodsMESH
ROC CurveMESH
Renal DialysisMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30611
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