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Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine

Gronwald, Wolfram ; Klein, Matthias S. ; Zeltner, Raoul ; Schulze, Bernd-Detlef ; Reinhold, Stephan W. ; Deutschmann, Markus ; Immervoll, Ann-Kathrin ; Böger, Carsten A. ; Banas, Bernhard ; Eckardt, Kai-Uwe ; Oefner, Peter J.


Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based classification and analyzed urine specimens of 54 patients with ADPKD and slightly ...


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