Jrad-Lamine, Aicha, Henry-Berger, Joelle, Gourbeyre, Pascal, Damon-Soubeyrand, Christelle, Lenoir, Alain, Combaret, Lydie, Saez, Fabrice, Kocer, Ayhan, Tone, Shigenobu, Fuchs, Dietmar, Zhu, Wentao, Oefner, Peter J., Munn, David H., Mellor, Andrew L., Gharbi, Najoua, Cadet, Rémi, Aitken, R. John and Drevet, Joël R. (2011) Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state. The Journal of biological chemistry 286 (10), pp. 8030-8042.
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Abstract
Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway. Intriguingly, IDO is constitutively and highly expressed in the mammalian epididymis in contrast to most other tissues where IDO is induced by proinflammatory cytokines, such as interferons. To gain insight into the role of IDO in the physiology of the mammalian ...
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| Item type: | Article | ||||||||||||||||||||||||||||||||
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| Date: | March 2011 | ||||||||||||||||||||||||||||||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) | ||||||||||||||||||||||||||||||||
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| Dewey Decimal Classification: | 500 Science > 500 Natural sciences & mathematics 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||||||||
| Created at the University of Regensburg: | Partially | ||||||||||||||||||||||||||||||||
| Item ID: | 30613 |
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