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Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state

Jrad-Lamine, Aicha ; Henry-Berger, Joelle ; Gourbeyre, Pascal ; Damon-Soubeyrand, Christelle ; Lenoir, Alain ; Combaret, Lydie ; Saez, Fabrice ; Kocer, Ayhan ; Tone, Shigenobu ; Fuchs, Dietmar ; Zhu, Wentao ; Oefner, Peter J. ; Munn, David H. ; Mellor, Andrew L. ; Gharbi, Najoua ; Cadet, Rémi ; Aitken, R. John ; Drevet, Joël R.



Abstract

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway. Intriguingly, IDO is constitutively and highly expressed in the mammalian epididymis in contrast to most other tissues where IDO is induced by proinflammatory cytokines, such as interferons. To gain insight into the role of IDO in the physiology of the mammalian ...

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