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Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state

Jrad-Lamine, Aicha, Henry-Berger, Joelle, Gourbeyre, Pascal, Damon-Soubeyrand, Christelle, Lenoir, Alain, Combaret, Lydie, Saez, Fabrice, Kocer, Ayhan, Tone, Shigenobu, Fuchs, Dietmar, Zhu, Wentao, Oefner, Peter J., Munn, David H., Mellor, Andrew L., Gharbi, Najoua, Cadet, Rémi, Aitken, R. John and Drevet, Joël R. (2011) Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state. The Journal of biological chemistry 286 (10), pp. 8030-8042.

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Abstract

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway. Intriguingly, IDO is constitutively and highly expressed in the mammalian epididymis in contrast to most other tissues where IDO is induced by proinflammatory cytokines, such as interferons. To gain insight into the role of IDO in the physiology of the mammalian ...

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Item type:Article
Date:March 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
21189261PubMed ID
10.1074/jbc.M110.172114DOI
Classification:
NotationType
AnimalsMESH
Epididymis/pathologyMESH
Gene Expression Regulation, EnzymologicMESH
Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolismMESH
Infertility, Male/pathologyMESH
Inflammation/pathologyMESH
Kynurenine/geneticsMESH
MaleMESH
MiceMESH
Mice, Inbred BALB CMESH
Mice, KnockoutMESH
Organ SpecificityMESH
Spermatozoa/pathologyMESH
Tryptophan/metabolismMESH
UbiquitinationMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30613
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