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Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia

Eberhart, Karin, Rainer, Johannes, Bindreither, Daniel, Ritter, Ireen, Gnaiger, Erich, Kofler, Reinhard, Oefner, Peter J. and Renner, Kathrin (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochimica et biophysica acta 1807 (6), pp. 719-725.

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Abstract

Mitochondria are signal-integrating organelles involved in cell death induction. Mitochondrial alterations and reduction in energy metabolism have been previously reported in the context of glucocorticoid (GC)-triggered apoptosis, although the mechanism is not yet clarified. We analyzed mitochondrial function in a GC-sensitive precursor B-cell acute lymphoblastic leukemia (ALL) model as well as ...

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Item type:Article
Date:June 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
21237131PubMed ID
10.1016/j.bbabio.2010.12.010DOI
Classification:
NotationType
Antineoplastic Agents, Hormonal/pharmacologyMESH
Cell Line, TumorMESH
Cell Respiration/geneticsMESH
Dexamethasone/pharmacologyMESH
Gene Expression ProfilingMESH
Gene Expression Regulation, Leukemic/drug effectsMESH
Glucocorticoids/pharmacologyMESH
HumansMESH
Microarray AnalysisMESH
Mitochondria/physiologyMESH
Mitochondrial Membranes/physiologyMESH
Oxygen Consumption/geneticsMESH
Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathologyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30617
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