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Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia

Eberhart, Karin ; Rainer, Johannes ; Bindreither, Daniel ; Ritter, Ireen ; Gnaiger, Erich ; Kofler, Reinhard ; Oefner, Peter J. ; Renner, Kathrin



Abstract

Mitochondria are signal-integrating organelles involved in cell death induction. Mitochondrial alterations and reduction in energy metabolism have been previously reported in the context of glucocorticoid (GC)-triggered apoptosis, although the mechanism is not yet clarified. We analyzed mitochondrial function in a GC-sensitive precursor B-cell acute lymphoblastic leukemia (ALL) model as well as ...

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