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Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase

Landfried, Karin, Zhu, Wentao, Waldhier, Magdalena Ch., Schulz, Ute, Ammer, Julia, Holler, Barbara, Wolff, Daniel, Edinger, Matthias, Peter, Katrin, Kreutz, Marina, Andreesen, Reinhard, Oefner, Peter J. and Holler, Ernst (2011) Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase. Blood 118 (26), pp. 6971-6974.

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Abstract

Induction of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in tryptophan degradation along the kynurenine pathway, acts as a potent immunoregulatory loop. To address its role in human allogeneic stem cell transplantation, we measured major tryptophan metabolites, such as quinolinic acid and kynurenine, in serial urine specimens from 51 patients by liquid chromatography-tandem mass ...

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Item type:Article
Date:December 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
22039265PubMed ID
10.1182/blood-2011-06-357814DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Chromatography, LiquidMESH
Gene Expression Regulation, EnzymologicMESH
Graft vs Host Disease/urineMESH
Hematopoietic Stem Cell Transplantation/methodsMESH
HumansMESH
Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolismMESH
Intestines/pathologyMESH
Kynurenine/urineMESH
Mass SpectrometryMESH
Middle AgedMESH
Quinolinic Acid/urineMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Severity of Illness IndexMESH
Time FactorsMESH
Transplantation, HomologousMESH
Tryptophan/urineMESH
Young AdultMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30620
Owner only: item control page
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