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Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase

Landfried, Karin ; Zhu, Wentao ; Waldhier, Magdalena Ch. ; Schulz, Ute ; Ammer, Julia ; Holler, Barbara ; Wolff, Daniel ; Edinger, Matthias ; Peter, Katrin ; Kreutz, Marina ; Andreesen, Reinhard ; Oefner, Peter J. ; Holler, Ernst



Abstract

Induction of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in tryptophan degradation along the kynurenine pathway, acts as a potent immunoregulatory loop. To address its role in human allogeneic stem cell transplantation, we measured major tryptophan metabolites, such as quinolinic acid and kynurenine, in serial urine specimens from 51 patients by liquid chromatography-tandem mass ...

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