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Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies

Stevens, Axel Peter, Dettmer, Katja, Kirovski, Georgi, Samejima, Keijiro, Hellerbrand, Claus, Bosserhoff, Anja-Katrin and Oefner, Peter J. (2010) Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies. Journal of chromatography A 1217 (19), pp. 3282-3288.

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Abstract

By means of liquid chromatography-tandem mass spectrometry we showed recently, that the chromosomal deletion or inactivation of the methylthioadenosine phosphorylase (MTAP) gene led to the accumulation of 5'-deoxy-5'-(methylthio)adenosine (MTA) in cancer cells. Here, we expanded the method to other key intermediates of the methionine and polyamine pathways to further elucidate the molecular ...

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Item type:Article
Date:7 May 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
20117790PubMed ID
10.1016/j.chroma.2010.01.025DOI
Classification:
NotationType
CalibrationMESH
Carcinoma, Hepatocellular/metabolismMESH
Cell Line, TumorMESH
Chromatography, Liquid/methodsMESH
HumansMESH
Liver Neoplasms/metabolismMESH
Methanol/chemistryMESH
Methionine/metabolismMESH
Polyamines/metabolismMESH
Purine-Nucleoside Phosphorylase/chemistryMESH
Regression AnalysisMESH
Reproducibility of ResultsMESH
Sensitivity and SpecificityMESH
Tandem Mass Spectrometry/methodsMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30631
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