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Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies

Stevens, Axel Peter ; Dettmer, Katja ; Kirovski, Georgi ; Samejima, Keijiro ; Hellerbrand, Claus ; Bosserhoff, Anja-Katrin ; Oefner, Peter J.


By means of liquid chromatography-tandem mass spectrometry we showed recently, that the chromosomal deletion or inactivation of the methylthioadenosine phosphorylase (MTAP) gene led to the accumulation of 5'-deoxy-5'-(methylthio)adenosine (MTA) in cancer cells. Here, we expanded the method to other key intermediates of the methionine and polyamine pathways to further elucidate the molecular ...


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