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Comparison of serum versus plasma collection in gas chromatography--mass spectrometry-based metabolomics

Dettmer, Katja ; Almstetter, Martin F. ; Appel, Inka ; Nürnberger, Nadine ; Schlamberger, Gregor ; Gronwald, Wolfram ; Meyer, Heinrich H. D. ; Oefner, Peter J.



Abstract

Bovine serum, EDTA-plasma and EDTA-plasma fortified with acetylsalicylic acid (ASA) as antioxidant were compared with regard to their suitability for metabolomic studies. Metabolic fingerprints were generated from GC-TOF-MS data using the Leco ChromaTOF software in combination with the in-house retention time correction and data alignment tool INCA. A total of 6, 9 and 21 significant features ...

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