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Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis

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Scholtysik, René ; Kreuz, Markus ; Klapper, Wolfram ; Burkhardt, Birgit ; Feller, Alfred ; Hummel, Michael ; Loeffler, Markus ; Rosolowski, Maciej ; Schwaenen, Carsten ; Spang, Rainer ; Stein, Harald ; Thorns, Christoph ; Trümper, Lorenz ; Vater, Inga ; Wessendorf, Swen ; Zenz, Thorsten ; Siebert, Reiner ; Küppers, Ralf
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 13 Aug 2014 08:52


The present findings suggest that uniparental disomies do not play a major role in the pathogenesis of Burkitt's lymphoma, whereas some genes may contribute to the development of this lymphoma through gene dosage effects. Amplifications of the polymerase iota gene may be functionally linked with increased genomic alterations in Burkitt's lymphoma. The pattern and rarity of chromosomal changes ...


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