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Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis

Scholtysik, René, Kreuz, Markus, Klapper, Wolfram, Burkhardt, Birgit, Feller, Alfred, Hummel, Michael, Loeffler, Markus, Rosolowski, Maciej, Schwaenen, Carsten, Spang, Rainer, Stein, Harald, Thorns, Christoph, Trümper, Lorenz, Vater, Inga, Wessendorf, Swen, Zenz, Thorsten, Siebert, Reiner and Küppers, Ralf (2010) Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis. Haematologica 95 (12), pp. 2047-2055.

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Abstract

The present findings suggest that uniparental disomies do not play a major role in the pathogenesis of Burkitt's lymphoma, whereas some genes may contribute to the development of this lymphoma through gene dosage effects. Amplifications of the polymerase iota gene may be functionally linked with increased genomic alterations in Burkitt's lymphoma. The pattern and rarity of chromosomal changes ...

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Item type:Article
Date:December 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
20823134PubMed ID
10.3324/haematol.2010.026831DOI
Classification:
NotationType
Burkitt Lymphoma/pathologyMESH
Chromosome AberrationsMESH
E2F2 Transcription Factor/geneticsMESH
Gene DosageMESH
Gene Expression Regulation, NeoplasticMESH
Gene RearrangementMESH
Genes, Immunoglobulin/geneticsMESH
Genome, Human/geneticsMESH
GenotypeMESH
HumansMESH
In Situ Hybridization, FluorescenceMESH
Loss of HeterozygosityMESH
MicroRNAs/geneticsMESH
Oligonucleotide Array Sequence Analysis/methodsMESH
Polymorphism, Single NucleotideMESH
Proto-Oncogene Proteins c-myc/geneticsMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Translocation, GeneticMESH
Uniparental DisomyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30640
Owner only: item control page

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