Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis

URN to cite this document:: urn:nbn:de:bvb:355-epub-306407
DOI to cite this document:: 10.5283/epub.30640

Scholtysik, René ; Kreuz, Markus ; Klapper, Wolfram ; Burkhardt, Birgit ; Feller, Alfred ; Hummel, Michael ; Loeffler, Markus ; Rosolowski, Maciej ; Schwaenen, Carsten ; Spang, Rainer ; Stein, Harald ; Thorns, Christoph ; Trümper, Lorenz ; Vater, Inga ; Wessendorf, Swen ; Zenz, Thorsten ; Siebert, Reiner ; Küppers, Ralf

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Date of publication of this fulltext: 13 Aug 2014 08:52

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Abstract

Background Knowledge about the genetic lesions that occur in Burkitt's lymphoma, besides the pathognomonic IG-MYC translocations, is limited. Design and Methods Thirty-nine molecularly-defined Burkitt's lymphomas were analyzed with high-resolution single-nucleotide polymorphism chips for genomic imbalances and uniparental disomy. Imbalances were correlated to expression profiles and selected ...