Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis

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Scholtysik, René ; Kreuz, Markus ; Klapper, Wolfram ; Burkhardt, Birgit ; Feller, Alfred ; Hummel, Michael ; Loeffler, Markus ; Rosolowski, Maciej ; Schwaenen, Carsten ; Spang, Rainer ; Stein, Harald ; Thorns, Christoph ; Trümper, Lorenz ; Vater, Inga ; Wessendorf, Swen ; Zenz, Thorsten ; Siebert, Reiner ; Küppers, Ralf

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Date of publication of this fulltext: 13 Aug 2014 08:52

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Details

Item type:	Article
Journal or Publication Title:	Haematologica
Publisher:	Ferrata Storti Foundation
Volume:	95
Number of Issue or Book Chapter:	12
Page Range:	pp. 2047-2055
Date:	December 2010
Institutions:	Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:	Value Type 20823134 PubMed ID 10.3324/haematol.2010.026831 DOI
Classification:	Notation Type Burkitt Lymphoma/pathology MESH Chromosome Aberrations MESH E2F2 Transcription Factor/genetics MESH Gene Dosage MESH Gene Expression Regulation, Neoplastic MESH Gene Rearrangement MESH Genes, Immunoglobulin/genetics MESH Genome, Human/genetics MESH Genotype MESH Humans MESH In Situ Hybridization, Fluorescence MESH Loss of Heterozygosity MESH MicroRNAs/genetics MESH Oligonucleotide Array Sequence Analysis/methods MESH Polymorphism, Single Nucleotide MESH Proto-Oncogene Proteins c-myc/genetics MESH Reverse Transcriptase Polymerase Chain Reaction MESH Translocation, Genetic MESH Uniparental Disomy MESH
Dewey Decimal Classification:	500 Science > 500 Natural sciences & mathematics 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	30640

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Abstract

The present findings suggest that uniparental disomies do not play a major role in the pathogenesis of Burkitt's lymphoma, whereas some genes may contribute to the development of this lymphoma through gene dosage effects. Amplifications of the polymerase iota gene may be functionally linked with increased genomic alterations in Burkitt's lymphoma. The pattern and rarity of chromosomal changes ...

Abstract

The present findings suggest that uniparental disomies do not play a major role in the pathogenesis of Burkitt's lymphoma, whereas some genes may contribute to the development of this lymphoma through gene dosage effects. Amplifications of the polymerase iota gene may be functionally linked with increased genomic alterations in Burkitt's lymphoma. The pattern and rarity of chromosomal changes detectable, even at the high resolution employed here, together with aberrations of genes regulating MYC activity, support the hypothesis that deregulation of the MYC pathway is the major force driving the pathogenesis of Burkitt's lymphoma, but show that this deregulation is more complex than previously known.

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Metadata last modified: 02 Jun 2018 07:44

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