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Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth

Amann, Thomas, Bataille, Frauke, Spruss, Thilo, Dettmer, Katja, Wild, Peter J., Liedtke, Christian, Mühlbauer, Marcus, Kiefer, Paul, Oefner, Peter J., Trautwein, Christian, Bosserhoff, Anja-Katrin and Hellerbrand, Claus (2010) Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth. The American journal of pathology 176 (3), pp. 1433-42.

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Abstract

Fibroblast growth factor receptor 2 isoform b (FGFR2-IIIb) is highly expressed in hepatocytes and plays an important role in liver homeostasis and regeneration. Here, we analyzed the expression and function of FGFR2-IIIb in hepatocellular carcinoma (HCC). FGFR2-IIIb expression in HCC tissues and cell lines was lower than in primary human hepatocytes and nontumorous tissue. FGFR2-IIIb-negative ...

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Item type:Article
Date:March 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
20093481PubMed ID
10.2353/ajpath.2010.090356DOI
Classification:
NotationType
AgedMESH
AnimalsMESH
Carcinoma, Hepatocellular/pathologyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
DNA Methylation/geneticsMESH
Down-Regulation/geneticsMESH
FemaleMESH
Fibroblast Growth Factor 7/pharmacologyMESH
Gene Expression Regulation, Neoplastic/drug effectsMESH
HumansMESH
Liver Neoplasms/pathologyMESH
MaleMESH
MiceMESH
Middle AgedMESH
Promoter Regions, Genetic/geneticsMESH
Protein Kinase Inhibitors/pharmacologyMESH
Pyrroles/pharmacologyMESH
Receptor, Fibroblast Growth Factor, Type 2/metabolismMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30644
Owner only: item control page
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