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Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth

Amann, Thomas ; Bataille, Frauke ; Spruss, Thilo ; Dettmer, Katja ; Wild, Peter J. ; Liedtke, Christian ; Mühlbauer, Marcus ; Kiefer, Paul ; Oefner, Peter J. ; Trautwein, Christian ; Bosserhoff, Anja-Katrin ; Hellerbrand, Claus



Abstract

Fibroblast growth factor receptor 2 isoform b (FGFR2-IIIb) is highly expressed in hepatocytes and plays an important role in liver homeostasis and regeneration. Here, we analyzed the expression and function of FGFR2-IIIb in hepatocellular carcinoma (HCC). FGFR2-IIIb expression in HCC tissues and cell lines was lower than in primary human hepatocytes and nontumorous tissue. FGFR2-IIIb-negative ...

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