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Planning the human variome project: the Spain report

Kaput, Jim ; Cotton, Richard G. H. ; Hardman, Lauren ; Watson, Michael ; Al Aqeel, Aida I. ; Al-Aama, Jumana Y. ; Al-Mulla, Fahd ; Alonso, Santos ; Aretz, Stefan ; Auerbach, Arleen D. ; Bapat, Bharati ; Bernstein, Inge T. ; Bhak, Jong ; Bleoo, Stacey L. ; Blöcker, Helmut ; Brenner, Steven E. ; Burn, John ; Bustamante, Mariona ; Calzone, Rita ; Cambon-Thomsen, Anne ; Cargill, Michele ; Carrera, Paola ; Cavedon, Lawrence ; Cho, Yoon Shin ; Chung, Yeun-Jun ; Claustres, Mireille ; Cutting, Garry ; Dalgleish, Raymond ; den Dunnen, Johan T. ; Díaz, Carlos ; Dobrowolski, Steven ; dos Santos, M. Rosário N. ; Ekong, Rosemary ; Flanagan, Simon B. ; Flicek, Paul ; Furukawa, Yoichi ; Genuardi, Maurizio ; Ghang, Ho ; Golubenko, Maria V. ; Greenblatt, Marc S. ; Hamosh, Ada ; Hancock, John M. ; Hardison, Ross ; Harrison, Terence M. ; Hoffmann, Robert ; Horaitis, Rania ; Howard, Heather J. ; Barash, Carol Isaacson ; Izagirre, Neskuts ; Jung, Jongsun ; Kojima, Toshio ; Laradi, Sandrine ; Lee, Yeon-Su ; Lee, Jong-Young ; Gil-da-Silva-Lopes, Vera L. ; Macrae, Finlay A. ; Maglott, Donna ; Marafie, Makia J. ; Marsh, Steven G. E. ; Matsubara, Yoichi ; Messiaen, Ludwine M. ; Möslein, Gabriela ; Netea, Mihai G. ; Norton, Melissa L. ; Oefner, Peter J. ; Oetting, William S. ; O'Leary, James C. ; de Ramirez, Ana Maria Oller ; Paalman, Mark H. ; Parboosingh, Jillian ; Patrinos, George P. ; Perozzi, Giuditta ; Phillips, Ian R. ; Povey, Sue ; Prasad, Suyash ; Qi, Ming ; Quin, David J. ; Ramesar, Rajkumar S. ; Richards, C Sue ; Savige, Judith ; Scheible, Dagmar G. ; Scott, Rodney J. ; Seminara, Daniela ; Shephard, Elizabeth A. ; Sijmons, Rolf H. ; Smith, Timothy D. ; Sobrido, María-Jesús ; Tanaka, Toshihiro ; Tavtigian, Sean V. ; Taylor, Graham R. ; Teague, Jon ; Töpel, Thoralf ; Ullman-Cullere, Mollie ; Utsunomiya, Joji ; van Kranen, Henk J. ; Vihinen, Mauno ; Webb, Elizabeth ; Weber, Thomas K. ; Yeager, Meredith ; Yeom, Young I. ; Yim, Seon-Hee ; Yoo, Hyang-Sook



Abstract

The remarkable progress in characterizing the human genome sequence, exemplified by the Human Genome Project and the HapMap Consortium, has led to the perception that knowledge and the tools (e.g., microarrays) are sufficient for many if not most biomedical research efforts. A large amount of data from diverse studies proves this perception inaccurate at best, and at worst, an impediment for ...

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