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Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models

Anchang, Benedict Nchang, Sadeh, Mohammad Javad, Jacob, Juby, Tresch, Achim, Vlad, Marcel O., Oefner, Peter J. and Spang, Rainer (2009) Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models. Proceedings of the National Academy of Sciences of the United States of America 106 (16), pp. 6447-6452.

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Abstract

Cellular decision making in differentiation, proliferation, or cell death is mediated by molecular signaling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signaling pathways. We introduce and describe a statistical method called Dynamic Nested Effects Model (D-NEM) for analyzing the temporal interplay of cell ...

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Item type:Article
Date:March 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
19329492PubMed ID
10.1073/pnas.0809822106DOI
Classification:
NotationType
AlgorithmsMESH
AnimalsMESH
Gene Expression RegulationMESH
MiceMESH
Models, GeneticMESH
Signal Transduction/geneticsMESH
Stem Cells/metabolismMESH
Time FactorsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30667
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