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Modeling the temporal interplay of molecular signaling and gene expression by using dynamic nested effects models

Anchang, Benedict Nchang ; Sadeh, Mohammad Javad ; Jacob, Juby ; Tresch, Achim ; Vlad, Marcel O. ; Oefner, Peter J. ; Spang, Rainer



Abstract

Cellular decision making in differentiation, proliferation, or cell death is mediated by molecular signaling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signaling pathways. We introduce and describe a statistical method called Dynamic Nested Effects Model (D-NEM) for analyzing the temporal interplay of cell ...

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