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Viral RNA and DNA trigger common antiviral responses in mesangial cells

Allam, Ramanjaneyulu, Lichtnekert, Julia, Moll, Anton G., Taubitz, Anela, Vielhauer, Volker and Anders, Hans-Joachim (2009) Viral RNA and DNA trigger common antiviral responses in mesangial cells. Journal of the American Society of Nephrology : JASN 20 (9), pp. 1986-1996.

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Abstract

Extrarenal viral infections commonly trigger glomerulonephritis, usually in association with immune complex disease. The Ig component of immune complexes can activate glomerular cell Fc receptors, but whether complexed viral nucleic acids contribute to glomerular inflammation remains unknown. Because of the types of Toll-like receptors (Tlrs) expressed by glomerular mesangial cells, we ...

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Item type:Article
Date:September 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
19713315PubMed ID
10.1681/ASN.2008101067DOI
Classification:
NotationType
AnimalsMESH
Apoptosis/immunologyMESH
Cell LineMESH
Chemokine CXCL10/metabolismMESH
CpG Islands/immunologyMESH
DNA, Viral/immunologyMESH
FemaleMESH
Gene Expression/immunologyMESH
Glomerulonephritis/virologyMESH
Glycoproteins/metabolismMESH
Immune Complex Diseases/virologyMESH
Interferons/metabolismMESH
Interleukin-6/metabolismMESH
Membrane Proteins/metabolismMESH
Mesangial Cells/virologyMESH
MiceMESH
Mice, Inbred C57BLMESH
Nerve Tissue Proteins/metabolismMESH
Oligonucleotide Array Sequence AnalysisMESH
RNA, Viral/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:30670
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