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Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins

Fischer, Andreas ; Baljuls, Angela ; Reinders, Jörg ; Nekhoroshkova, Elena ; Sibilski, Claudia ; Metz, Renate ; Albert, Stefan ; Rajalingam, Krishnaraj ; Hekman, Mirko ; Rapp, Ulf R.



Abstract

Mammalian 14-3-3 proteins play a crucial role in the activation process of RAF kinases. However, little is known about the selectivity of the mammalian 14-3-3 isoforms with respect to RAF association and activation. Using mass spectrometry, we analyzed the composition of the 14-3-3 isoforms attached to RAF kinases and found that B-RAF associates in vivo with 14-3-3 at much higher diversity than ...

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