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Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins

Fischer, Andreas, Baljuls, Angela, Reinders, Jörg, Nekhoroshkova, Elena, Sibilski, Claudia, Metz, Renate, Albert, Stefan, Rajalingam, Krishnaraj, Hekman, Mirko and Rapp, Ulf R. (2009) Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins. The Journal of biological chemistry 284 (5), pp. 3183-3194.

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Abstract

Mammalian 14-3-3 proteins play a crucial role in the activation process of RAF kinases. However, little is known about the selectivity of the mammalian 14-3-3 isoforms with respect to RAF association and activation. Using mass spectrometry, we analyzed the composition of the 14-3-3 isoforms attached to RAF kinases and found that B-RAF associates in vivo with 14-3-3 at much higher diversity than ...

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Item type:Article
Date:January 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
19049963PubMed ID
10.1074/jbc.M804795200DOI
Classification:
NotationType
14-3-3 Proteins/physiologyMESH
Base SequenceMESH
Binding SitesMESH
Biosensing TechniquesMESH
DNA PrimersMESH
DimerizationMESH
Electrophoresis, Polyacrylamide GelMESH
HeLa CellsMESH
HumansMESH
ImmunoprecipitationMESH
Protein Isoforms/physiologyMESH
Tandem Mass SpectrometryMESH
raf Kinases/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30675
Owner only: item control page
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