Huber, Stefan, Antoni, Frauke, Schickaneder, Christian, Schickaneder, Helmut, Bernhardt, Günther and Buschauer, Armin (2015) Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC. Journal of Pharmaceutical and Biomedical Analysis 104, pp. 137-143.
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Abstract
Esters of the cytostatic bendamustine (1), previously demonstrated to be much more potent than the parent compound as antiproliferative agents in vitro, were investigated by HPLC for stability in buffer and plasma, as well as against porcine liver esterase in the presence of different amounts of albumin. The hydrolysis of the nitrogen mustard moiety was retarded (for 1: approximately 130 vs. 11 ...
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| Item type: | Article | ||||||
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| Date: | 2015 | ||||||
| Additional Information (public): | Supplementary Material available online | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||
| Identification Number: |
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| Keywords: | Bendamustine ester, nitrogen mustard, hydrolysis, butyrylcholinesterase, ester cleavage, HPLC | ||||||
| Dewey Decimal Classification: | 600 Technology > 615 Pharmacy | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 30722 |
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