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Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC

Huber, Stefan ; Antoni, Frauke ; Schickaneder, Christian ; Schickaneder, Helmut ; Bernhardt, Günther ; Buschauer, Armin



Abstract

Esters of the cytostatic bendamustine (1), previously demonstrated to be much more potent than the parent compound as antiproliferative agents in vitro, were investigated for stability in buffer and plasma, as well as against porcine liver esterase in the presence of different amounts of albumin using a validated RP-HPLC method with fluorescence detection. The hydrolysis of the nitrogen mustard ...

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