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Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC

Huber, Stefan, Antoni, Frauke, Schickaneder, Christian, Schickaneder, Helmut, Bernhardt, Günther and Buschauer, Armin (2015) Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC. Journal of Pharmaceutical and Biomedical Analysis 104, pp. 137-143.

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Abstract

Esters of the cytostatic bendamustine (1), previously demonstrated to be much more potent than the parent compound as antiproliferative agents in vitro, were investigated by HPLC for stability in buffer and plasma, as well as against porcine liver esterase in the presence of different amounts of albumin. The hydrolysis of the nitrogen mustard moiety was retarded (for 1: approximately 130 vs. 11 ...

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Item type:Article
Date:2015
Additional Information (public):Supplementary Material available online
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.1016/j.jpba.2014.11.038DOI
25499654PubMed ID
Related URLs:
URLURL Type
http://www.sciencedirect.com/science/article/pii/S0731708514005731Publisher
Keywords:Bendamustine ester, nitrogen mustard, hydrolysis, butyrylcholinesterase, ester cleavage, HPLC
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30722
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