Go to content
UR Home

Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC

Huber, Stefan ; Antoni, Frauke ; Schickaneder, Christian ; Schickaneder, Helmut ; Bernhardt, Günther ; Buschauer, Armin


Esters of the cytostatic bendamustine (1), previously demonstrated to be much more potent than the parent compound as antiproliferative agents in vitro, were investigated by HPLC for stability in buffer and plasma, as well as against porcine liver esterase in the presence of different amounts of albumin. The hydrolysis of the nitrogen mustard moiety was retarded (for 1: approximately 130 vs. 11 ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons