Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage

URN to cite this document:: urn:nbn:de:bvb:355-epub-312149
DOI to cite this document:: 10.5283/epub.31214

Herrnberger, Leonie ; Hennig, Robert ; Kremer, Werner ; Hellerbrand, Claus ; Goepferich, Achim ; Kalbitzer, Hans Robert ; Tamm, Ernst R.

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Date of publication of this fulltext: 09 Jan 2015 13:46

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Abstract

Liver sinusoidal endothelial cells (LSEC) are characterized by the presence of fenestrations that are not bridged by a diaphragm. The molecular mechanisms that control the formation of the fenestrations are largely unclear. Here we report that mice, which are deficient in plasmalemma vesicle-associated protein (PLVAP), develop a distinct phenotype that is caused by the lack of sinusoidal ...