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Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin

Lübker, Carolin ; Bieber-Urbauer, Ramona J. ; Moskovitz, Jackob ; Dove, Stefan ; Weisemann, Jasmin ; Fedorova, Maria ; Urbauer, Jeffrey L. ; Seifert, Roland


Membranous adenylyl cyclase 1 (AC1) is associated with memory and learning. AC1 is activated by the eukaryotic Ca2+-sensor calmodulin (CaM), which contains nine methionine residues (Met) important for CaM-target interactions. During ageing, Met residues are oxidized to (S)- and (R)-methionine sulfoxide (MetSO) by reactive oxygen species arising from an age-related oxidative stress. We examined ...


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