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TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning

URN to cite this document:
urn:nbn:de:bvb:355-epub-312878
Diermeier, Sarah Daniela Helena ; Kolovos, Petros ; Heizinger, Leonhard ; Schwartz, Uwe ; Georgomanolis, Theodore ; Zirkel, Anne ; Wedemann, Gero ; Grosveld, Frank ; Knoch, Tobias A. ; Merkl, Rainer ; Cook, Peter R. ; Längst, Gernot ; Papatonis, Argyris
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Date of publication of this fulltext: 05 Feb 2015 07:26


Abstract

Background The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new transcriptional programs. Results Using micrococcal nuclease treatment and high-throughput sequencing, we map genome-wide changes in nucleosome ...

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