TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning

URN to cite this document:: urn:nbn:de:bvb:355-epub-312878
DOI to cite this document:: 10.5283/epub.31287

Diermeier, Sarah Daniela Helena ; Kolovos, Petros ; Heizinger, Leonhard ; Schwartz, Uwe ; Georgomanolis, Theodore ; Zirkel, Anne ; Wedemann, Gero ; Grosveld, Frank ; Knoch, Tobias A. ; Merkl, Rainer ; Cook, Peter R. ; Längst, Gernot ; Papatonis, Argyris

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Date of publication of this fulltext: 05 Feb 2015 07:26

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Abstract

Background The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new transcriptional programs. Results Using micrococcal nuclease treatment and high-throughput sequencing, we map genome-wide changes in nucleosome ...