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TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning

Diermeier, Sarah Daniela Helena, Kolovos, Petros, Heizinger, Leonhard, Schwartz, Uwe, Georgomanolis, Theodore, Zirkel, Anne, Wedemann, Gero, Grosveld, Frank, Knoch, Tobias A., Merkl, Rainer, Cook, Peter R., Längst, Gernot and Papatonis, Argyris (2014) TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning. Genome Biology 15 (12).

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Date of publication of this fulltext: 05 Feb 2015 07:26

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Other URL: http://genomebiology.com/2014/15/12/536


Abstract

Background The rearrangement of nucleosomes along the DNA fiber profoundly affects gene expression, but little is known about how signalling reshapes the chromatin landscape, in three-dimensional space and over time, to allow establishment of new transcriptional programs. Results Using micrococcal nuclease treatment and high-throughput sequencing, we map genome-wide changes in nucleosome ...

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Item type:Article
Date:3 December 2014
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13059-014-0536-6DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31287
Owner only: item control page

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