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Luciferase complementation for the determination of arrestin recruitment: Investigations at histamine and NPY receptors

Felixberger, Johannes (2016) Luciferase complementation for the determination of arrestin recruitment: Investigations at histamine and NPY receptors. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Feb 2016 06:38

Abstract (English)

Progress in our understanding of GPCRs and the functional versatility of these signal transduction machineries requires an extension of the methodology used for ligand characterization to account for alternate signaling pathways. This thesis aimed at the establishment of an arrestin recruitment assay to allow the characterization of newly developed ligand classes with respect to alternate, ...

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Translation of the abstract (German)

Ziel dieser Arbeit war die Etablierung eines Arrestinrekrutierungsassays zur Charakterisierung neuer Ligandklassen in Bezug auf alternative, Arrestin vermittelte Signaltransduktionswege. Der optimierte Luciferase-Komplementationsassay hat sich als eine schnelle und zuverlässige Methode zur Untersuchung der ligandinduzierten Arrestinrekrutierung an GPCRs erwiesen. Durch den gewählten modularen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2 February 2016
Referee:Prof. Dr. Armin Buschauer
Date of exam:30 January 2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:GPCR, Arrestin, G-Protein, funktionelle Selektivität, biased agonism, pharmacological characterization, functional selectivity
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31292
Owner only: item control page

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