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Investigations on bendamustine esters as new antitumor agents and the role of ABCG2 as a surrogate marker of breast cancer initiating cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-314379
DOI to cite this document:
10.5283/epub.31437
Huber, Stefan
Date of publication of this fulltext: 11 Mar 2016 12:40


Abstract (English)

ABC-transporter expression is a crucial mechanism of tumor resistance and was recently also associated with cancer initiating cells (CIC). Flow cytometry was applied to detect the expression of CIC-markers, ABCB1 and ABCG2 in human brain- and breast cancer cell lines and to examine possible correlations between ABC-transporter expression and CICs. Only one of the investigated brain tumor cell ...

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Translation of the abstract (German)

Die Expression von ABC-Transportern ist nicht nur ein wesentlicher Mechanismus der Tumorresistenz, sondern wurde in der Vergangenheit auch mit Krebs-initiierenden Zellen (KIZ) in Verbindung gebracht. Zur Untersuchung möglicher Zusammenhänge zwischen der Expression von ABC-Transportern und KIZ wurde mittels Durchflusszytometrie die Expression von KIZ-Markern sowie von ABCB1 und ABCG2 in humanen ...

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