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Investigations on bendamustine esters as new antitumor agents and the role of ABCG2 as a surrogate marker of breast cancer initiating cells

Huber, Stefan (2016) Investigations on bendamustine esters as new antitumor agents and the role of ABCG2 as a surrogate marker of breast cancer initiating cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 11 Mar 2016 12:40

Abstract (English)

ABC-transporter expression is a crucial mechanism of tumor resistance and was recently also associated with cancer initiating cells (CIC). Flow cytometry was applied to detect the expression of CIC-markers, ABCB1 and ABCG2 in human brain- and breast cancer cell lines and to examine possible correlations between ABC-transporter expression and CICs. Only one of the investigated brain tumor cell ...

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Translation of the abstract (German)

Die Expression von ABC-Transportern ist nicht nur ein wesentlicher Mechanismus der Tumorresistenz, sondern wurde in der Vergangenheit auch mit Krebs-initiierenden Zellen (KIZ) in Verbindung gebracht. Zur Untersuchung möglicher Zusammenhänge zwischen der Expression von ABC-Transportern und KIZ wurde mittels Durchflusszytometrie die Expression von KIZ-Markern sowie von ABCB1 und ABCG2 in humanen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:11 March 2016
Referee:Prof. Dr. Armin Buschauer
Date of exam:6 March 2015
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Bendamustin, ester, stability, cytotoxicity, breast cancer initiating cells, Topotecan, ABCG2
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:31437
Owner only: item control page

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