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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-314995
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.31499
Zusammenfassung
Introduction Rheumatoid arthritis (RA) is characterized by decreased androgen levels, which was the first hormonal abnormality described. Several studies indicated that steroidogenesis is directed towards endogenous glucocorticoids at the expense of androgens. The decisive step governing androgen synthesis is the 17,20-lyase activity of the CYP17A1 gene-encoded enzyme cytochrome P450 17A1. Here, ...
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