Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-318902
DOI to cite this document:: 10.5283/epub.31890

Engelmann, Julia C.

; Amann, Thomas ; Ott-Rötzer, Brigitta ; Nützel, Margit ; Reinders, Yvonne ; Reinders, Jörg ; Thasler, Wolfgang E. ; Kristl, Theresa ; Teufel, Andreas ; Huber, Christian G.

; Oefner, Peter J.

; Spang, Rainer ; Hellerbrand, Claus

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Date of publication of this fulltext: 29 May 2015 09:54

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Abstract

Inter-cellular communication with stromal cells is vital for cancer cells. Molecules involved in the communication are potential drug targets. To identify them systematically, we applied a systems level analysis that combined reverse network engineering with causal effect estimation. Using only observational transcriptome profiles we searched for paracrine factors sending messages from activated ...