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Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma

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Engelmann, Julia C. ; Amann, Thomas ; Ott-Rötzer, Brigitta ; Nützel, Margit ; Reinders, Yvonne ; Reinders, Jörg ; Thasler, Wolfgang E. ; Kristl, Theresa ; Teufel, Andreas ; Huber, Christian G. ; Oefner, Peter J. ; Spang, Rainer ; Hellerbrand, Claus
Date of publication of this fulltext: 29 May 2015 09:54


Inter-cellular communication with stromal cells is vital for cancer cells. Molecules involved in the communication are potential drug targets. To identify them systematically, we applied a systems level analysis that combined reverse network engineering with causal effect estimation. Using only observational transcriptome profiles we searched for paracrine factors sending messages from activated ...


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