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Neuronale alpha-adrenerge Stimulation von IFN-gamma, IL-6 und CXCL1 in murinen Milzen im Tiermodell der Arthritisspätphase

Meinel, Thomas Raphael (2015) Neuronale alpha-adrenerge Stimulation von IFN-gamma, IL-6 und CXCL1 in murinen Milzen im Tiermodell der Arthritisspätphase. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Aug 2015 09:54

at publisher (via DOI)

Other URL: http://linkinghub.elsevier.com/retrieve/pii/S0889-1591(13)00227-4


Abstract (German)

Es war vorbekannt, dass sympathische Nervenfasern mit Zytokin-produzierenden Zellen in der Milz von Mäusen in der Frühphase (Tag 32) des CIA-Modells kommunizieren (STRAUB). Diese Daten zeigten jeweils ausschließlich eine neuronale sympathische Regulation von IFN-y, CXCL1, IL-6 und TGF-ß. Allerdings könnte sich diese Schnittstelle in der Spätphase der CIA durch den Verlust sympathischer ...

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Translation of the abstract (English)

Objective: Functional cross-talk exists between sympathetic nerve fibers and cytokine-producing splenic cells in early collagen type II–induced arthritis (CIA) (day 32). These earlier experiments demonstrated exclusively neuronal sympathetic regulation of IFN-c, CXCL1, IL-6, and TGF-b. However, in late arthritis, the sympathetic influence might change due to loss of sympathetic nerve fibers and ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:14 August 2015
Referee:Prof. Dr. Rainer H. Straub
Date of exam:30 July 2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Orthopädie
Projects:DFG Research Unit (Forschergruppe) FOR696
Identification Number:
ValueType
10.1016/j.bbi.2013.06.003DOI
Keywords:sympathetic nervous system, spleen, chronic experimental arthritis, neurotransmitters, cytokines, SNS, Sympathisches Nervensystem, Neurotransmitter, Zytokine, CIA, Arthritismodell, Milz
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32314
Owner only: item control page

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