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Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation

Beermann, Silke ; Bernhardt, Guenther ; Seifert, Roland ; Buschauer, Armin ; Neumann, Detlef



Abstract

The histamine (HA) receptor subtype 1 (H1R) and H4R are expressed on immune cells and contribute to an inflammatory reaction. Both receptor subtypes individually enhance the intracellular concentrations of calcium and regulate the accumulation of cAMP, increase MAPK activity, and regulate expression of e.g. inflammatory genes. In a previous study we characterized and compared signaling pathways ...

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