Structure-dependent deconjugation of flavonoid glucuronides by human beta-glucuronidase - in vitro and in silico analyses

Untergehrer, Monika ; Bücherl, Daniel ; Wittmann, Hans-Joachim ; Strasser, Andrea ; Heilmann, Jörg ; Jürgenliemk, Guido

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Zusammenfassung

Flavonoid glycosides are extensively metabolized to glucuronidated compounds after oral intake. Recently, a cleavage of quercetin glucuronides by -glucuronidase has been found. To characterize the deglucuronidation reaction and its structural prerequisites among the flavonoid subtypes more precisely, four flavonol glucuronides with varying glucuronidation positions, five flavone 7-O-glucuronides ...