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Implementation and applications of gas chromatography/ atmospheric pressure chemical ionization time-of-flight mass spectrometry in metabolomics

Wachsmuth, Christian J. (2015) Implementation and applications of gas chromatography/ atmospheric pressure chemical ionization time-of-flight mass spectrometry in metabolomics. PhD, Universität Regensburg.

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Date of publication of this fulltext: 23 Oct 2015 12:00

Abstract (English)

With the commercial introduction of atmospheric pressure chemical ionization for gas chromatography in 2008, GC-APCI coupled to high-resolution time-of-flight mass spectrometry (GC-APCI-HRTOFMS) became an interesting addition to the metabolomics toolbox. APCI is a soft ionization technique and its application to hyphenate GC to high resolution MS opens up promising new means for the ...

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Translation of the abstract (German)

Mit der kommerziellen Einführung der chemischen Ionisation bei Atmosphärendruck für die Gaschromatographie im Jahr 2008 wurde GC-APCI in Kombination mit hochauflösender Massenspektrometrie (GC-APCI-HRTOFMS) als zusätzliches Verfahren für das Methodenspektrum in der Metabolomik interessant. Bei der APCI handelt es sich um eine weiche Ionisationstechnik. In Kombination mit GC und hochauflösender MS ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:23 October 2015
Referee:Prof. Dr. Peter Oefner and Prof. Dr. Frank-Michael Matysik
Date of exam:19 October 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Instrumentelle Analytik (Prof. Frank-Michael Matysik)
Keywords:Gas chromatography/ atmospheric pressure chemical ionization time-of-flight mass spectrometry, GC-APCI-TOFMS, gas chromatograhy, atmospheric pressure chemical ionization, mass spectrometry, metabolite identification, metabolomics, ionization efficiency, D-2-hydroxyglutarate
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32638
Owner only: item control page

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