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The Microbiome and Allogeneic Stem Cell Transplantation

Sporrer, Daniela, Gessner, Andre, Hehlgans, Thomas, Oefner, Peter J. and Holler, Ernst (2015) The Microbiome and Allogeneic Stem Cell Transplantation. Current Stem Cell Reports 1, pp. 53-59.

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Graft-versus-host disease (GvHD) is the major cause of mortality and morbidity after allogeneic stem cell transplantation. Recently, deep sequencing of the hypervariable regions of the 16S rRNA gene in stool specimens significantly enhanced our understanding of a likely pathophysiologic role of the microbiome in GvHD. Here, we summarize the indirect and direct evidence for a microbiome ...


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Item type:Article
Date:15 January 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Immunologie
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
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Keywords:Allogeneic stem cell transplantation; GvHD; Microbiome; Receptors of innate immunity; Intestinal immuneregulation; Antimicrobial peptides
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:32758
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