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Identification of critical regions within the TIR domain of IL-1 receptor type I

Radons, Jürgen, Falk, Werner and Dove, Stefan (2015) Identification of critical regions within the TIR domain of IL-1 receptor type I. The international journal of biochemistry & cell biology 68, pp. 15-20.

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Other URL: http://www.sciencedirect.com/science/article/pii/S1357272515300042


Interleukin-1 receptor type I (IL-1RI) belongs to a superfamily of proteins characterized by an intracellular Toll/IL-1 receptor (TIR) domain. This domain harbors three conserved regions called boxes 1-3 that play crucial roles in mediating IL-1 responses. Boxes 1 and 2 are considered to be involved in binding of adapter molecules. Amino acids possibly crucial for IL-1RI signaling were predicted ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
26279140PubMed ID
Keywords:IL-1; IL-1RI; TIR domain; NF-κB; Site-directed mutagenesis; Homology modeling
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33094
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