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Towards Chiralomics: Targeted and Untargeted Gas Chromatography-Mass Spectrometry based Enantioselective Metabolome Analysis

Waldhier, Magdalena C. (2016) Towards Chiralomics: Targeted and Untargeted Gas Chromatography-Mass Spectrometry based Enantioselective Metabolome Analysis. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jan 2016 12:56

Abstract (English)

Chirality is not a rare phenomenon in metabolomes. Nevertheless, common metabolomics approaches still detect enantiomers as a single signal. However, they are individual metabolites due to different stereospecific enzymes catalyzing their metabolism. The here presented methods consider the configuration of chiral metabolites in the interpretation of metabolomics data to investigate the following ...

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Translation of the abstract (German)

Viele Stoffwechselprodukte sind chiral, werden aber in der Metabolomik meist nicht getrennt bestimmt. Stereoisomere sind jedoch auf Grund der Stereospezifizität der meisten Enzyme, die für ihren Auf- und Abbau verantwortlich sind, eigenständige Stoffwechselprodukte und Veränderungen in ihrer Abundanz können Aufschluss über gestörte Stoffwechselwege geben. So sind D-Aminosäuren (D-As), die zwar in ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:14 January 2016
Referee:Prof. Dr. Frank-Michael Matysik
Date of exam:18 December 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Keywords:metabolomics, enantiomers, gas chromatography-mass spectrometry, non-alcoholic fatty liver disease, chiralomics. Metabolomik, Enantiomere, Gaschromatographie-Massenspektrometrie, Nichtalkoholische Fettleber, Chiralomik
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33122
Owner only: item control page

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