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Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population

Raschenberger, J., Kollerits, B., Titze, S., Kottgen, A., Barthlein, B., Ekici, A. B., Forer, L., Schonherr, S., Weissensteiner, H., Haun, M., Wanner, C., Eckardt, K. U., Kronenberg, F., Eckardt, K. U., Titze, S., Meiselbach, H., Schneider, M., Dienemann, T., Prokosch, H. U., Barthlein, B., Reis, A., Ekici, A. B., Gefeller, O., Hilgers, K. F., Hubner, S., Avendano, S., Becker-Grosspitsch, D., Hausknecht, B., Zitzmann, R., Weigel, A., Beck, A., Ganslandt, T., Knispel, S., Dressel, T., Kottgen, A., Schultheiss, U., Meder, S., Mitsch, E., Reinhard, U., Walz, G., Floege, J., Schlieper, G., Saritas, T., Ernst, S., Lipski, S., Schaeffner, E., Baid-Agrawal, S., Petzold, K., Kielstein, J. T., Haller, H., Lorenzen, J., Otto, P., Sommerer, C., Follinger, C., Zeier, M., Busch, M., Wolf, G., Paul, K., Dittrich, L., Fuss, R., Hilge, R., Sitter, T., Blank, C., Wanner, C., Krane, V., Toncar, S., Schmiedeke, D., Cavitt, D., Schonowsky, K., Borner-Klein, A., Kronenberg, F., Raschenberger, J., Kollerits, B., Forer, L., Schonherr, S., Weissensteiner, H., Oefner, Peter J., Gronwald, Wolfram, Zacharias, Helena, Schmid, M. and Nadal, J. (2015) Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population. Exp. Gerontol. 72 (162), pp. 162-166.

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Other URL: http://www.sciencedirect.com/science/article/pii/S0531556515300619


Abstract

Telomere length is considered as a biological marker for aging. It is expected that telomeres shorten with age and with conditions associated with oxidative stress and inflammation. Both are present in patients with chronic kidney disease (CKD) who have a very high cardiovascular risk. We investigated whether CKD duration is associated with relative telomere length (RTL) in 4802 patients from the ...

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Item type:Article
Date:December 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1016/j.exger.2015.09.019DOI
Keywords:Telomere length; Kidney disease; Telomerase activity; Disease duration
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:33596
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