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Structure of the leech protein saratin and characterization of its binding to collagen

Gronwald, Wolfram ; Bomke, J. ; Maurer, T. ; Domogalla, B. ; Huber, F. ; Schumann, F. ; Kremer, W. ; Fink, F. ; Rysiok, T. ; Frech, M. ; Kalbitzer, Hans Robert



Abstract

The leech protein Saratin from Hirudo medicinalis prevents thrombocyte aggregation by interfering with the first binding step of the thrombocytes to collagen by binding to collagen. We solved the three-dimensional structure of the leech protein Saratin in solution and identified its collagen binding site by NMR titration experiments. The NMR structure of Saratin consists of one α-helix and a ...

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