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Functional Expression of the Interleukin-11 Receptor α-Chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells

Kießling, Stephan ; Müller-Newen, Gerhard ; Leeb, Sandra N. ; Hausmann, Martin ; Rath, Heiko C. ; Strater, Jörn ; Spottl, Tanja ; Schlottmann, Klaus ; Grossmann, Johannes ; Montero-Julian, F. A. ; Schölmerich, Jürgen ; Andus, Tilo ; Buschauer, Armin ; Heinrich, Peter C. ; Rogler, Gerhard


A tissue-protective effect of interleukin-11 (IL-11) for the intestinal mucosa has been postulated from animal models of inflammatory bowel disease (IBD). Despite the fact that the clinical usefulness of the anti-inflammatory effects of this cytokine is presently investigated in patients with IBD, there are no data available regarding the target cells of IL-11 action and the mechanisms of tissue ...


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