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Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.

Hubensack, Martina ; Müller, Christine ; Höcherl, Höcherl ; Fellner, Stephan ; Spruss, Thilo ; Bernhardt, Günther ; Buschauer, Armin
Date of publication of this fulltext: 05 Aug 2009 13:42


Abstract

PURPOSE: Previously, we studied the effect of co-administration of paclitaxel with the second generation ABCB1 (p-gp) modulator valspodar on the intracerebral growth of human U118-MG glioblastoma in nude mice. Valspodar significantly increased the brain levels of paclitaxel by inhibition of p-gp expressed at the blood brain barrier. Thus, the tumour burden was reduced by 90%, which was considered ...

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