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Isoenzyme-specific differences in the degradation of hyaluronic acid by mammalian-type hyaluronidases.

Hofinger, Edith S. A. ; Hoechstetter, Julia ; Oettl, Martin ; Bernhardt, Günther ; Buschauer, Armin



Abstract

Bovine testicular hyaluronidase (BTH) has been used as a spreading factor for many years and was primarily characterized by its enzymatic activity. As recombinant human hyaluronidases are now available the bovine preparations can be replaced by the human enzymes. However, data on the pH-dependent activity of hyaluronidases reported in literature are inconsistent in part or even contradictory. ...

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