Lieb, Sebastian, Michaelis, Stefanie, Plank, Nicole, Bernhardt, Günther, Buschauer, Armin and Wegener, Joachim (2016) Label-free analysis of GPCR-stimulation: The critical impact of cell adhesion. Pharmacological Research 108 (June), pp. 65-74.
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Abstract
Label-free cell-based assays have been attracting growing attention in drug research. Optical approaches based on evanescent electric fields (e.g. EPIC, RWG/DMR, SPR) and electrochemical impedance analysis (ECIS, xCELLigence) are by far the most widespread techniques for such purposes. We compared three label-free approaches (ECIS, RWG/DMR and SPR) with respect to the activation of the human ...
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| Item type: | Article | ||||||
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| Date: | 2016 | ||||||
| Additional Information (public): | Supplementary Material available online. | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Bioanalytik und Biosensorik (Prof. Joachim Wegener) | ||||||
| Projects: | GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands" | ||||||
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| Keywords: | Label-free; cell-based assays; G-protein coupled receptors; holistic; ECIS; SPR; dynamic mass redistribution (DMR) | ||||||
| Dewey Decimal Classification: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 33747 |
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