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Label-free analysis of GPCR-stimulation: The critical impact of cell adhesion

Lieb, Sebastian, Michaelis, Stefanie, Plank, Nicole, Bernhardt, Günther, Buschauer, Armin and Wegener, Joachim (2016) Label-free analysis of GPCR-stimulation: The critical impact of cell adhesion. Pharmacological Research 108 (June), pp. 65-74.

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Abstract

Label-free cell-based assays have been attracting growing attention in drug research. Optical approaches based on evanescent electric fields (e.g. EPIC, RWG/DMR, SPR) and electrochemical impedance analysis (ECIS, xCELLigence) are by far the most widespread techniques for such purposes. We compared three label-free approaches (ECIS, RWG/DMR and SPR) with respect to the activation of the human ...

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Item type:Article
Date:2016
Additional Information (public):Supplementary Material available online.
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Bioanalytik und Biosensorik (Prof. Joachim Wegener)
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1016/j.phrs.2016.04.026DOI
27133553PubMed ID
Related URLs:
URLURL Type
http://www.sciencedirect.com/science/article/pii/S1043661816303772Publisher
Keywords:Label-free; cell-based assays; G-protein coupled receptors; holistic; ECIS; SPR; dynamic mass redistribution (DMR)
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33747
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