Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist.

DOI to cite this document:: 10.5283/epub.3375

Schneider, Erich

; Keller, Max ; Brennauer, Albert ; Hoefelschweiger, Bianca K. ; Gross, Dietmar ; Wolfbeis, Otto S.

; Bernhardt, Günther ; Buschauer, Armin

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Date of publication of this fulltext: 05 Aug 2009 13:42

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Abstract

Cyanine-5-labelled neuropeptide Y (NPY) was demonstrated to be an ideal universal fluorescent ligand for the combined investigation of NPY Y-1, Y-2 and Y-5 receptors. With respect to improved stability, detection of receptor subtypes in cells and tissues, and prevention of receptor internalization, small nonpeptidic fluorescent 1 antagonists should be superior. Here we present a set of four ...