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Synthesis and Characterization of the First Fluorescent Nonpeptide NPY Y1 Receptor Antagonist.

Schneider, Erich ; Keller, Max ; Brennauer, Albert ; Hoefelschweiger, Bianca K. ; Gross, Dietmar ; Wolfbeis, Otto S. ; Bernhardt, Günther ; Buschauer, Armin
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Date of publication of this fulltext: 05 Aug 2009 13:42


Abstract

Cyanine-5-labelled neuropeptide Y (NPY) was demonstrated to be an ideal universal fluorescent ligand for the combined investigation of NPY Y1, Y2 and Y5 receptors. With respect to improved stability, detection of receptor subtypes in cells and tissues, and prevention of receptor internalization, small nonpeptidic fluorescent antagonists should be superior. Here we present a set of four ...

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