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Recombinant human hyaluronidase Hyal-1: insect cells versus E. coli as expression system and identification of low molecular weight inhibitors.

Hofinger, Edith S. A. ; Spickenreither, Martin ; Oschmann, Jan ; Bernhardt, Günther ; Rudolph, Rainer ; Buschauer, Armin



Abstract

The human hyaluronidase Hyal-1, one of six human hyaluronidase subtypes, preferentially degrades hyaluronic acid present in the extracellular matrix of somatic tissues. Modulations of Hyal-1 expression have been observed in a number of malignant tumors. However, its role in disease progression is discussed controversially due to limited information on enzyme properties as well as the lack of ...

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