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Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.

Müller, Christine ; Gross, Dietmar ; Sarli, Vasiliki ; Gartner, Michael ; Giannis, Athanassios ; Bernhardt, Günther ; Buschauer, Armin



Abstract

The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Therefore, we studied the effects of the new monastrol analogues enastron, dimethylenastron and vasastrol VS-83 on the proliferation of human glioblastoma cells in the kinetic crystal violet assay. ...

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