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Design of new benzoxazole-2-thione derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.

Rigden, Daniel J. ; Botzki, Alexander ; Nukui, Masatoshi ; Mewbourne, R. Brandon ; Lamani, Ejvis ; Braun, Stephan ; von Angerer, Erwin ; Bernhardt, Günther ; Dove, Stefan ; Buschauer, Armin ; Jedrzejas, Mark J.


The bacterial hyaluronan lyases (Hyals) that degrade hyaluronan, an important component of the extracellular matrix, are involved in microbial spread. Inhibitors of these enzymes are essential in investigation of the role of hyaluronan and Hyal in bacterial infections and constitute a new class of antibiotics against Hyal-producing bacteria. Recently, we identified ...


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