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Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,

Botzki, Alexander, Salmen, Sunnhild, Bernhardt, Günther, Buschauer, Armin and Dove, Stefan (2005) Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,. QSAR & Combinatorial Science 24 (4), pp. 458-469.

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Other URL: http://www3.interscience.wiley.com/cgi-bin/abstract/109925329/ABSTRACT


Hyaluronidases depolymerize hyaluronic acid, an important component of the extracellular matrix. Bacterial hyaluronan lyases (EC contribute to the spreading of microorganisms in tissues. Potent and selective inhibitors are not known up to now, but would be interesting pharmacological tools and potential drugs for the treatment of bacterial infections. Starting from two crystal structures ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
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Keywords:Hyaluronidase inhibitors • LUDI • Property distribution • Structure-based design
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:3389
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