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Structure-Based Design Of Bacterial Hyaluronan Lyase Inhibitors,

Botzki, Alexander ; Salmen, Sunnhild ; Bernhardt, Günther ; Buschauer, Armin ; Dove, Stefan


Hyaluronidases depolymerize hyaluronic acid, an important component of the extracellular matrix. Bacterial hyaluronan lyases (EC contribute to the spreading of microorganisms in tissues. Potent and selective inhibitors are not known up to now, but would be interesting pharmacological tools and potential drugs for the treatment of bacterial infections. Starting from two crystal structures ...


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