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Structure-Activity Relationships of Nonpeptide Neuropeptide Y Receptor Antagonists

Brennauer, Albert ; Dove, Stefan ; Buschauer, Armin


Reports in 1990 on some weakly to moderately active nonpeptides which were not originally designed for neuropeptide Y (NPY) receptors, followed by the discovery of the first highly potent and selective Y1 receptor antagonists-the (R)-argininamide BIBP 3226 and the benzamidine deriv. SR 120819A-as well as raising hope for novel drug treatment of hypertension, obesity and metabolic diseases ...


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