Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy

URN to cite this document:: urn:nbn:de:bvb:355-epub-339394
DOI to cite this document:: 10.5283/epub.33939

Ehrenschwender, Martin ; Knoll, Gertrud ; Bittner, Sebastian ; Kurz, Maria ; Jantsch, Jonathan

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Date of publication of this fulltext: 24 Jun 2016 12:44

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Abstract

The capacity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to selectively induce cell death in malignant cells triggered numerous attempts for therapeutic exploitation. In clinical trials, however, TRAIL did not live up to the expectations, as tumors exhibit high rates of TRAIL resistance in vivo. Response to anti-cancer therapy is determined not only by cancer cell intrinsic ...