Go to content
UR Home

Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy

Ehrenschwender, Martin, Knoll, Gertrud, Bittner, Sebastian, Kurz, Maria and Jantsch, Johnathan (2016) Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy. Oncotarget 2016, pp. 1-17.

[img]
Preview
PDF
Download (7MB)
Date of publication of this fulltext: 24 Jun 2016 12:44

at publisher (via DOI)

Other URL: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9206&pubmed-linkout=1


Abstract

The capacity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to selectively induce cell death in malignant cells triggered numerous attempts for therapeutic exploitation. In clinical trials, however, TRAIL did not live up to the expectations, as tumors exhibit high rates of TRAIL resistance in vivo. Response to anti-cancer therapy is determined not only by cancer cell intrinsic ...

plus


Export bibliographical data



Item type:Article
Date:6 May 2016
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.18632/oncotarget.9206DOI
Keywords:TRAIL, SMAC mimetic, death receptor, hypoxia
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33939
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons