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Comparative characterization of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae in pharmaceutical preparations

Oettl, Martin ; Hoechstetter, Julia ; Asen, Iris ; Bernhardt, Günther ; Buschauer, Armin


Although bovine testicular hyaluronidase (BTH) has been used in several medical fields for many years, these drugs are poorly characterized. We compared pharmaceutical BTH preparations (Neopermease®, Hylase® “Dessau”) and a hyaluronate lyase from Streptococcus agalactiae. The BTH preparations were complex mixtures of proteins (SDS–PAGE, gel filtration) with enzymatic activity in different ...


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