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Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation

Weber, Daniela ; Oefner, Peter J. ; Dettmer, Katja ; Hiergeist, Andreas ; Koestler, Josef ; Gessner, Andre ; Weber, Markus ; Stämmler, Frank ; Hahn, Joachim ; Wolff, Daniel ; Herr, Wolfgang ; Holler, Ernst


Intestinal dysbiosis has been associated with acute gastrointestinal GvHD and poor outcome following allogeneic stem cell transplantation (ASCT). To assess the effect of a switch in 2012 from ciprofloxacin/metronidazole to rifaximin for gut decontamination on intestinal microbiota composition and ASCT outcome, we retrospectively analyzed 394 patients receiving ASCT from September 2008 through ...


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