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Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2

Seliger, Corinna, Meyer, A. L., Renner, K., Leidgens, V., Moeckel, S., Jachnik, B., Dettmer, Katja, Tischler, U., Gerthofer, V., Rauer, L., Uhl, M., Proescholdt, M., Bogdahn, U., Riemenschneider, M. J., Oefner, Peter J., Kreutz, M., Vollmann-Zwerenz, A. and Hau, Peter (2016) Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2. Cell Cycle 15 (13), pp. 1755-1766.

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Other URL: http://www.tandfonline.com/doi/full/10.1080/15384101.2016.1186316


To this day, glioblastoma (GBM) remains an incurable brain tumor. Previous research has shown that metformin, an oral anti-diabetic drug, may decrease GBM cell proliferation and migration especially in brain tumor initiating cells (BTICs). As transforming growth factor β 2 (TGF-β2) has been reported to promote high-grade glioma and is inhibited by metformin in other tumors, we explored whether ...


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Item type:Article
Date:10 May 2016
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
27163626PubMed ID
Keywords:AMPK; BTIC; SMAD; TGF-β2; glioblastoma; mTOR; metformin
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33991
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