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Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2

Seliger, Corinna ; Meyer, A. L. ; Renner, K. ; Leidgens, V. ; Moeckel, S. ; Jachnik, B. ; Dettmer, Katja ; Tischler, U. ; Gerthofer, V. ; Rauer, L. ; Uhl, M. ; Proescholdt, M. ; Bogdahn, U. ; Riemenschneider, M. J. ; Oefner, Peter J. ; Kreutz, M. ; Vollmann-Zwerenz, A. ; Hau, Peter


To this day, glioblastoma (GBM) remains an incurable brain tumor. Previous research has shown that metformin, an oral anti-diabetic drug, may decrease GBM cell proliferation and migration especially in brain tumor initiating cells (BTICs). As transforming growth factor 2 (TGF-(2)) has been reported to promote high-grade glioma and is inhibited by metformin in other tumors, we explored whether ...


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