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Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,

Wenzel-Seifert, Katharina, Kelley, Melissa T., Buschauer, Armin and Seifert, Roland (2001) Similar apparent constitutive activity of human histamine H_2-receptor fused to long and short splice variants of Gsa,. Journal of Pharmacology and Experimental Therapeutics 299 (3), pp. 1013-1020.

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Other URL: http://jpet.aspetjournals.org/cgi/content/full/299/3/1013


Abstract

Fusion proteins allow for the analysis of receptor/G protein coupling under defined conditions. The beta 2-adrenoceptor (beta 2AR) fused to the long splice variant of Gsalpha (Gsalpha L) exhibits a higher apparent constitutive activity than the beta 2-adrenoceptor fused to the short splice variant of Gsalpha (Gsalpha S). Experimentally, this results in higher efficacy and potency of partial ...

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Item type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
11714890PubMed ID
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:3402
Owner only: item control page
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