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Programmable biodegradable implants

Vogelhuber, W. ; Rutunno, P. ; Magni, E. ; Gazzaniga, A. ; Spruss, Thilo ; Bernhardt, Günther ; Buschauer, Armin ; Goepferich, Achim



Abstract

Pulsatile release implants were developed that release substances up to 58 days post implantation. With a cylindrical size of 2 mm diameter and 1.8 mm height the matrices can carry as much as 1 mg of drug and allow even for intracranial implantation into a rodent model. The matrices are made of materials that have been used for parenteral applications in humans before such as surface eroding ...

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