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Limited signal transduction repertoire of human Y_5 neuropeptide Y receptors expressed in HEC-B cells

Bischoff, Andrea ; Püttmann, Kristina ; Kötting, Annette ; Moser, Christiane ; Buschauer, Armin ; Michel, Martin C.



Abstract

In HEC-1B cells transfected with human Y5 neuropeptide Y (NPY) receptors (but not in non-transfected cells) NPY inhibited forskolin-stimulated cAMP accumulation in a pertussis toxin-sensitive manner (−log EC50 8.88 ± 0.25). Elevations of intracellular Ca2+ were largely restricted to very high NPY concentrations and similar in transfected and nontransfected cells. NPY did not increase inositol ...

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