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Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry

Aronov, P. A., Hall, L. M., Dettmer, Katja, Stephensen, C. B. and Hammock, B. D. (2008) Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 391 (5), pp. 1917-1930.

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Other URL: http://link.springer.com/article/10.1007%2Fs00216-008-2095-8


Abstract

Biologically active forms of vitamin D are important analytical targets in both research and clinical practice. The current technology is such that each of the vitamin D metabolites is usually analyzed by individual assay. However, current LC-MS technologies allow the simultaneous metabolic profiling of entire biochemical pathways. The impediment to the metabolic profiling of vitamin D ...

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Item type:Article
Date:July 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
18437365PubMed ID
10.1007/s00216-008-2095-8DOI
Keywords:1α,25-DihydroxyvitaminD3; 25-Hydroxyvitamin D3; 24R,25-Dihydroxyvitamin D3; UPLC; LC-MS; Metabolic profiling; Derivatization
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34316
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