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Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group

Kroiss, R. ; Winkler, V. ; Kalteis, K. ; Bikas, D. ; Rudas, M. ; Tea, M. ; Fuerhauser, C. ; Muhr, D. ; Cerny, H. ; Glueck, S. ; Petru, E. ; Concin, H. ; Kubista, E. ; Oefner, Peter J.


Purpose BRCA1 mutation carriers are at high risk for breast cancer (BC). The risk management strategy may include radiological investigations for early detection or prophylactic mastectomy (PM). For a mutation carrier, PM may be more significant than surveillance alone when pre-malignant and malignant changes occur increasingly in mastectomy specimens, given normal findings on radiological ...


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