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Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group

Kroiss, R. ; Winkler, V. ; Kalteis, K. ; Bikas, D. ; Rudas, M. ; Tea, M. ; Fuerhauser, C. ; Muhr, D. ; Cerny, H. ; Glueck, S. ; Petru, E. ; Concin, H. ; Kubista, E. ; Oefner, Peter J.



Abstract

Purpose BRCA1 mutation carriers are at high risk for breast cancer (BC). The risk management strategy may include radiological investigations for early detection or prophylactic mastectomy (PM). For a mutation carrier, PM may be more significant than surveillance alone when pre-malignant and malignant changes occur increasingly in mastectomy specimens, given normal findings on radiological ...

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