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Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group

Kroiss, R., Winkler, V., Kalteis, K., Bikas, D., Rudas, M., Tea, M., Fuerhauser, C., Muhr, D., Cerny, H., Glueck, S., Petru, E., Concin, H., Kubista, E. and Oefner, Peter J. (2008) Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group. Journal of Cancer Research and Clinical Oncology 134 (10), pp. 1113-1121.

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Other URL: http://link.springer.com/article/10.1007%2Fs00432-008-0383-5


Abstract

Purpose BRCA1 mutation carriers are at high risk for breast cancer (BC). The risk management strategy may include radiological investigations for early detection or prophylactic mastectomy (PM). For a mutation carrier, PM may be more significant than surveillance alone when pre-malignant and malignant changes occur increasingly in mastectomy specimens, given normal findings on radiological ...

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Item type:Article
Date:October 2008
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
18392852PubMed ID
10.1007/s00432-008-0383-5DOI
Keywords:Breast cancer; BRCA; Prophylactic mastectomy; Pre-malignant lesions; Malignant lesions
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:34322
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